Participant information
Participant information
If you're thinking of taking part in the trial, here is some additional information about what is involved.
This clinical trial is testing how effective different drugs are at slowing down the progression of motor neuron disease (MND). These drugs are already approved to treat other medical conditions.
If you take part in the trial, you will be given one of the active drugs or a dummy drug (placebo). You will be asked to take the medicine once a day. It will be in a liquid form.
During the trial we will review how well the medicines are working whilst people are still taking the study drugs, rather than just at the end. If, at a review point, a medicine does not appear to be performing well you will be asked to stop taking it. You may be able to start MND-SMART again if new drugs are added to the trial. This is known as an ‘adaptive trial’.
During the trial, neither you nor the doctor or nurse treating you will know which medicine you are taking. This is to make sure that the results of the trial are unbiased.
Tests
- blood tests
- an ECG (a routine heart trace)
- breathing assessments
- questionnaires about physical functioning, your mood and your MND
- cognitive assessments (memory, problem solving etc)
Clinic visits and follow up
Side effects
Who can take part?
- diagnosed with MND
- over the age of 18
- living in the UK
- not pregnant or breastfeeding
Do I have to take part?