Scientific publications
Scientific publications
A list of our scientific publications related to MND-SMART. The publications describe our methodology and results in detail. All these published articles have been "peer-reviewed", which means that they have been scrutinised by two or three independent experts.
2023
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus
- Detailed description of the systematic, structured and evidence-based approach used to select the first two drugs used in MND-SMART (trazodone and memantine). Read more in the news article: New publication: How we selected drugs for the MND-SMART clinical trial.
Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART)
Parker RA, Weir CJ, Pham TM, White IR, Stallard N, Parmar MKB, Swingler RJ, Dakin RS, Pal S, Chandran S. Trials. 2023 Jan 16;24(1):29. doi: 10.1186/s13063-022-07007-z.
- Detailed description of the statistical analyses that will be applied to the trial data. The plan has been designed to minimise bias, and maximise the likelihood of deriving accurate results that give clinically meaningful information about the treatment effects of the drugs being tested.
2022
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease
Wong C, Dakin RS, Williamson J, Newton J, Steven M, Colville S, Stavrou M, Gregory JM, Elliott E, Mehta AR, Chataway J, Swingler RJ, Parker RA, Weir CJ, Stallard N, Parmar MKB, Macleod MR, Pal S, Chandran S. BMJ Open. 2022 Jul 7;12(7):e064173. doi: 10.1136/bmjopen-2022-064173.
- Detailed description of the MND-SMART trial protocol. Read more in the news article: MND Study Protocol Published
2021
Prospective observational cohort study of factors influencing trial participation in people with motor neuron disease (FIT-participation-MND): a protocol
Beswick E, Glasmacher SA, Dakin R, Newton J, Carson A, Abrahams S, Chandran S, Pal S. BMJ Open. 2021 Mar 23;11(3):e044996. doi: 10.1136/bmjopen-2020-044996.
- This paper describes the protocol for an MND-SMART substudy, which examined the factors that affect whether people join MND-SMART, and crucially, what affects whether they stay in the trial. Improved understanding of these factors may improve trial protocol design, optimise recruitment and retention. Read more in the news article: MND-SMART substudy 1