a selection of scientific papers strewn randomly

Scientific publications

Scientific publications

A list of our scientific publications related to MND-SMART. The publications describe our methodology and results in detail. All these published articles have been "peer-reviewed", which means that they have been scrutinised by two or three independent experts.


Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus
Wong C, Gregory JM, Liao J, et al.doi: 10.1136/bmjopen-2022-064169
Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART)

Parker RA, Weir CJ, Pham TM, White IR, Stallard N, Parmar MKB, Swingler RJ, Dakin RS, Pal S, Chandran S. Trials. 2023 Jan 16;24(1):29. doi: 10.1186/s13063-022-07007-z.

  • Detailed description of the statistical analyses that will be applied to the trial data. The plan has been designed to minimise bias, and maximise the likelihood of deriving accurate results that give clinically meaningful information about the treatment effects of the drugs being tested.


Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Wong C, Dakin RS, Williamson J, Newton J, Steven M, Colville S, Stavrou M, Gregory JM, Elliott E, Mehta AR, Chataway J, Swingler RJ, Parker RA, Weir CJ, Stallard N, Parmar MKB, Macleod MR, Pal S, Chandran S. BMJ Open. 2022 Jul 7;12(7):e064173. doi: 10.1136/bmjopen-2022-064173.


Prospective observational cohort study of factors influencing trial participation in people with motor neuron disease (FIT-participation-MND): a protocol

Beswick E, Glasmacher SA, Dakin R, Newton J, Carson A, Abrahams S, Chandran S, Pal S. BMJ Open. 2021 Mar 23;11(3):e044996. doi: 10.1136/bmjopen-2020-044996.

  • This paper describes the protocol for an MND-SMART substudy, which examined the factors that affect whether people join MND-SMART, and crucially, what affects whether they stay in the trial. Improved understanding of these factors may improve trial protocol design, optimise recruitment and retention. Read more in the news article: MND-SMART substudy 1